Distinct event-related-potential biomarkers of broad versus specific dimensions of the Hierarchical Taxonomy of Psychopathology externalizing spectrum.

Journal article

Patrick C. J., Ribes-Guardiola P., Bartholow B. D., Kallen A. M., Perkins E. R., Krueger R. F., ..., Forbes M. K., ..., & Joyner K. J.
Clinical Psychological Science, vol. 0(0), 2025, p. 21677026251414032

DOI: 10.1177/21677026251414032

Sage Journals

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APA Click to copy
Patrick, C. J., Ribes-Guardiola, P., Bartholow, B. D., Kallen, A. M., Perkins, E. R., Krueger, R. F., … & Joyner K. J. (2025). Distinct event-related-potential biomarkers of broad versus specific dimensions of the Hierarchical Taxonomy of Psychopathology externalizing spectrum. Clinical Psychological Science, 0(0), 21677026251414032. https://doi.org/10.1177/21677026251414032

Chicago/Turabian Click to copy
Patrick, C. J., P. Ribes-Guardiola, B. D. Bartholow, A. M. Kallen, E. R. Perkins, R. F. Krueger, ..., M. K. Forbes, ..., and & Joyner K. J. “Distinct Event-Related-Potential Biomarkers of Broad versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum.” Clinical Psychological Science 0, no. 0 (2025): 21677026251414032.

MLA Click to copy
Patrick, C. J., et al. “Distinct Event-Related-Potential Biomarkers of Broad versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum.” Clinical Psychological Science, vol. 0, no. 0, 2025, p. 21677026251414032, doi:10.1177/21677026251414032.

BibTeX Click to copy

@article{patrick2025a,
  title = {Distinct event-related-potential biomarkers of broad versus specific dimensions of the Hierarchical Taxonomy of Psychopathology externalizing spectrum.},
  year = {2025},
  issue = {0},
  journal = {Clinical Psychological Science},
  pages = {21677026251414032},
  volume = {0},
  doi = {10.1177/21677026251414032},
  author = {Patrick, C. J. and Ribes-Guardiola, P. and Bartholow, B. D. and Kallen, A. M. and Perkins, E. R. and Krueger, R. F. and ... and Forbes, M. K. and ... and J., & Joyner K.}
}

Abstract

The Hierarchical Taxonomy of Psychopathology (HiTOP) provides a dimensional framework for connecting psychological disorders to neural systems/processes. We examined how neurophysiological measures of cognitive-attentional (oddball P300) and perceptual-emotional processing (fear-face N170/P200) relate to dimensions of the HiTOP externalizing spectrum. Employing 666 community participants, we fit a model in which antagonistic externalizing and substance-problems subfactors, defined via symptom and questionnaire-scale measures, loaded with a disinhibitory trait scale onto a higher-order externalizing factor. Hierarchical regression was used to evaluate how much observed relations of each neural measure with the two subfactors reflected their unique variance versus their covariance (reflected in the general factor). P300’s relations were fully accounted for by the general factor, suggesting that impaired cognitive processing characterizes broad risk for externalizing problems. Neural indicators of sensitivity to others’ distress (N170, P200) were uniquely related to antagonistic externalizing. Findings highlight the HiTOP framework’s potential to advance biobehavioral understanding of psychopathology.