APA
Click to copy
Mewton, L., Lees, B., Squeglia, L. M., Forbes, M. K., Sunderland, M., Krueger, R., … Teesson, M. (2021). The relationship between brain structure and general psychopathology in preadolescents. Journal of Child Psychology and Psychiatry, 63(7), 734–744. https://doi.org/10.1111/jcpp.13513
Chicago/Turabian
Click to copy
Mewton, Louise, Briana Lees, Lindsay M. Squeglia, Miriam K. Forbes, Matthew Sunderland, Robert Krueger, Forrest C. Koch, et al. “The Relationship between Brain Structure and General Psychopathology in Preadolescents.” Journal of Child Psychology and Psychiatry 63, no. 7 (September 1, 2021): 734–744.
MLA
Click to copy
Mewton, Louise, et al. “The Relationship between Brain Structure and General Psychopathology in Preadolescents.” Journal of Child Psychology and Psychiatry, vol. 63, no. 7, Wiley-Liss, Wiley, Sept. 2021, pp. 734–44, doi:10.1111/jcpp.13513.
BibTeX Click to copy
@article{mewton2021a,
title = {The relationship between brain structure and general psychopathology in preadolescents},
year = {2021},
month = sep,
day = {1},
issue = {7},
journal = {Journal of Child Psychology and Psychiatry},
pages = {734–744},
publisher = {Wiley-Liss, Wiley},
volume = {63},
doi = {10.1111/jcpp.13513},
author = {Mewton, Louise and Lees, Briana and Squeglia, Lindsay M. and Forbes, Miriam K. and Sunderland, Matthew and Krueger, Robert and Koch, Forrest C. and Baillie, Andrew and Slade, Tim and Hoy, Nicholas and Teesson, Maree},
month_numeric = {9}
}
An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging.
This study included baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study® (n = 11,875; age range = 9–10 years; male = 52.2%). General psychopathology, externalizing, internalizing, and thought disorder dimensions were based on a higher-order model of psychopathology and estimated using Bayesian plausible values. Outcome variables included global and regional cortical volume, thickness, and surface area.
Higher levels of psychopathology across all dimensions were associated with lower volume and surface area globally, as well as widespread and pervasive alterations across the majority of cortical and subcortical regions studied, after adjusting for sex, race/ethnicity, parental education, income, and maternal psychopathology. The relationships between general psychopathology and brain structure were attenuated when adjusting for cognitive functioning. There were no statistically significant relationships between psychopathology and cortical thickness in this sample of preadolescents.
The current study identified lower cortical volume and surface area as transdiagnostic biomarkers for general psychopathology in preadolescence. Future research may focus on whether the widespread and pervasive relationships between general psychopathology and brain structure reflect cognitive dysfunction that is a feature across a range of mental illnesses.
